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为了探讨肠上皮化生在胃癌发生方面的意义，作者采用粘液组织化学染色、核仁组成体区相关嗜银蛋白（ＡｇＮＯＲ）染色等方法研究了９３例胃癌癌旁肠上皮化生的特点。结果显示癌旁肠上皮化生的检出率为８０．６４％，大肠型肠上皮化生检出率５８．０６％，不完全性大肠型肠上皮化生检出率１７．２０％；７例早期胃癌中５例伴有肠上皮化生；肠上皮化生及其各种亚型在肠型胃癌和弥漫型胃癌之间的差别无显著意义（Ｐ＞０．０５）；肠上皮化生ＡｇＮＯＲ数目（２．１５±０．４９）明显多于正常幽门腺（Ｐ＜０．０１），ＡｇＮＯＲ直径（１．５８±０．４８μｍ）明显小于正常幽门腺（Ｐ＜０．０５），与胃癌细胞的差别均无显著意义。讨论认为伴有明显异型增生的肠上皮化生属于胃癌的癌前病变。
In order to investigate the significance of intestinal metaplasia in the development of gastric cancer, the authors studied the characteristics of paratypic metaplasia in 93 cases of gastric cancer by mucin histochemical staining and AgNOR staining. The results showed that the detection rate of paratumor metaplasia was 80.64%, the detection rate of intestinal metaplasia was 58.06%, and the detection rate of incomplete intestinal metaplasia was 17.20%; 7 Five cases of early gastric cancer were associated with intestinal metaplasia; Intestinal metaplasia and its various subtypes had no significant difference between intestinal type gastric cancer and diffuse type gastric cancer (P>0.05); intestinal metaplasia The number of AgNOR (2.15±0.49) was significantly higher than that of normal pyloric gland (P<0.01), and the AgNOR diameter (1.58±0.48 μm) was significantly smaller than that of normal pyloric gland (P<0.05). There was no significant difference in gastric cancer cells. It is considered that intestinal metaplasia with marked dysplasia is a precancerous lesion of gastric cancer.