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目的 探讨激素替代治疗 (HRT)对绝经后妇女体内抗氧化能力的影响。方法 将受试者 6 2例分为两组。从未接受HRT的绝经后妇女 31例 (对照组 ) ;已接受HRT的绝经后妇女 31例 (观察组 )。所有受试者均测空腹血清总抗氧化能力 (TAOC) ,丙二醛 (MDA) ,过氧化物歧化酶 (SOD)。结果 与对照组比较 ,观察组的TAOC显著上升 (P <0 .0 5 ) ,MDA明显下降 (P <0 .0 1) ,SOD显著上升 (P <0 .0 5 )。结论 绝经后妇女长期应用HRT可以降低氧化应力 ,提高机体清除活性氧的能力 ,对心血管具有一定的保护作用。
Objective To investigate the effect of hormone replacement therapy (HRT) on the anti-oxidative capacity of postmenopausal women. Methods Sixty-two subjects were divided into two groups. Thirty-one postmenopausal women who had never received HRT (control group); 31 postmenopausal women who had received HRT (observation group). All subjects were measured fasting serum total antioxidant capacity (TAOC), malondialdehyde (MDA), superoxide dismutase (SOD). Results Compared with the control group, TAOC in the observation group increased significantly (P <0.05), MDA decreased significantly (P <0.01), SOD increased significantly (P <0.05). Conclusion Long-term application of HRT in postmenopausal women can reduce oxidative stress and improve the body’s ability to scavenge reactive oxygen species, which has a certain protective effect on cardiovascular.