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大颗粒淋巴细胞(large granular lymphocytes, LGL)白血病是一类以循环中大颗粒淋巴细胞异常增多为特征的疾病、根据细胞起源不同分为T蛳LGL和NK蛳LGL,它们形态学相似,但表面抗原、临床特征和预后等方面有显著不同。本文综述了LGL白血病在发病机制、免疫表型和治疗方面的新进展。
Large granular lymphocytes (LGL) leukemias are a group of diseases characterized by an abnormal increase of circulating large granule lymphocytes. They are divided into T 蛳 LGL and NK 蛳 LGL according to the origin of the cells. They are morphologically similar, but the surface Antigen, clinical features and prognosis were significantly different. This article reviews the recent advances in the pathogenesis, immunophenotyping and treatment of LGL leukemia.