目的以经介入治疗的胆管癌合并阻塞性黄疸患者为研究对象,探讨可能影响胆管癌介入疗效的因素。方法回顾分析45例胆管癌合并阻塞性黄疸患者资料,以生存时间为观察指标,并对可能影响生存率的因素如性别、发病年龄、发生部位、病理分化程度、术前胆红素水平、术前肝功能、引流方式、有无并发症、有无后续治疗等进行比较。结果胆道内支架组生存时间大于单纯胆道外引流组(P=0.048<0.05);经皮肝穿刺胆道引流术(PTCD)后进行后续治疗组生存时间大于无后续治疗组(P=0.0001<0.05);肝功能按照Child-pugh分级分为A级、B级、C级,A级组生存时间最长,C级最短(P=0.0042<0.05);按组织学分化类型分为高分化腺癌组、中分化腺癌组、低分化腺癌组,高分化腺癌组生存时间最长,低分化腺癌组最短(P=0.045<0.05);按照术前总胆红素水平分为小于180μmol/L组1、80～360μmol/L组、大于360μmol/L组,小于180μmol/L组生存时间最长,大于360μmol/L组最短(P=0.0039〈0.05);男性组与女性组生存时间无差别(P=0.346>0.05);按照年龄分为<40岁组、40～60岁组、>60岁组;3组生存时间无差别(P=0.781>0.05);按发病部位分为上、中、下三段,3组生存时间无差别(P=0.714>0.05);有并发症组与无并发症组生存时间无差别(P=0.911>0.05)。结论引流方式、有无后续治疗、组织分化类型、术前总胆红素水平、肝功能等因素影响胆管癌合并阻塞性黄疸介入疗效 Objective To study the interventional treatment of cholangiocarcinoma patients with obstructive jaundice, and to explore the factors that may affect the interventional effect of cholangiocarcinoma. Methods The data of 45 patients with cholangiocarcinoma complicated with obstructive jaundice were retrospectively analyzed. The survival time was taken as the observation index. The factors influencing survival rate, such as sex, age of onset, site of occurrence, pathological differentiation, preoperative bilirubin level, Pre-liver function, drainage, with or without complications, with or without follow-up treatment were compared. Results The survival time of the biliary stent group was longer than that of the simple biliary drainage group (P = 0.048 <0.05). The survival time of the follow-up group after the percutaneous transhepatic biliary drainage (PTCD) was higher than that without the continuous treatment group (P = 0.0001 <0.05) ; The liver function was classified into A grade, B grade and C grade according to Child-pugh classification, the longest survival time and the shortest C grade (P = 0.0042 <0.05). The histological differentiation type was divided into well-differentiated adenocarcinoma group (P = 0.045 <0.05) .According to the preoperative total bilirubin level, the survival time was the longest, the rate was less than 180μmol / L in the differentiated adenocarcinoma group, the poorly differentiated adenocarcinoma group and the well- In L group, the survival time was the longest in the groups of 1, 80-360μmol / L and 360μmol / L, the longest in the group of less than 180μmol / L, the shortest in the group of 360μmol / L (P = 0.0039 <0.05) (P = 0.346> 0.05). There were no differences in survival time between the three groups (P = 0.781> 0.05) according to the age group <40 years old, 40-60 years old,> 60 years old. (P = 0.714> 0.05). There was no difference in the survival time between the two groups (P = 0.911> 0.05). Conclusion The drainage methods, with or without follow-up treatment, the type of tissue differentiation, preoperative total bilirubin levels, liver function and other factors affect the efficacy of interventional treatment of cholangiocarcinoma with obstructive jaundice