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采用10％蛋清致大鼠关节炎症模型,给大鼠连续30天灌胃肩痛丸后,高、中、低剂量 (2．4、1．2、0．6生药／kg)组动物的足肿胀度明显低于模型组,表明肩痛丸对大鼠关节炎症性肿胀具有明显的抑制作用。经放免法测定,对因炎症引起的大鼠血浆TXB2 升高有明显的降低作用,同时可升高雌性大鼠的血清水平,对血浆6-keto-PGF1a和血清T等水平未见明显影响,提示本品临床应用时的消炎、镇痛作用与抑制环氧化酶活性、调节雌性激素水平等有一定相关性。实验目的:用鸡蛋清造成关节炎症模型, 观察肩痛丸灌胃给药后对关节炎症模型的治疗作用,同时观察对激素(E2、T)及 TXB2、6-keto-PGF1a的影响。
Using a 10% egg white-induced rat model of joint inflammation, the rats were treated with high-, medium-, and low-dose (2.4, 1.2, and 0.6 crude drug/kg) animals for 30 days. The degree of swelling was significantly lower than that of the model group, suggesting that shoulder pain pills have a significant inhibitory effect on inflammatory swelling of rat joints. The radioimmunoassay method can significantly reduce the increase of plasma TXB2 in rats induced by inflammation, and increase the serum level of female rats. There is no significant effect on plasma 6-keto-PGF1a and serum T levels. It is suggested that the anti-inflammatory and analgesic effects of this product in clinical application are related to the inhibition of cyclooxygenase activity and the regulation of estrogen levels. Purpose of the experiment: Use an egg white to model the joint inflammation, observe the therapeutic effect of shoulder pain pills on arthritis model after intragastric administration, and observe the effect on hormone (E2, T) and TXB2, 6-keto-PGF1a.