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[目的]研究分析血液病患者发生真菌感染的危险因素,提高对真菌感染的认识。[方法]对收治的45例血液病患者化疗后发生真菌感染的诊治资料进行回顾性分析,主要调查其临床特征、化疗情况、抗生素、抗真菌药物、免疫抑制剂和激素药物的使用等情况,并记录病原菌培养结果、治疗方案、感染部位、真菌学疗效等。[结果]根据细菌培养和药敏试验结果,所有病例均确诊为合并真菌感染,确诊后均进行抗真菌治疗。分析发现接受化疗、抗生素治疗、免疫抑制剂治疗均是血液病患者发生真菌感染的危险因素。[结论]血液病患者面临着真菌感染的多种危险因素,具有病原体复杂和感染部位多等特点。
[Objective] To study and analyze the risk factors of fungal infection in patients with hematological diseases and improve their understanding of fungal infections. [Methods] The clinical data of 45 patients with hematological diseases who underwent chemotherapy after fungal chemotherapy were retrospectively analyzed. The clinical features, the status of chemotherapy, the use of antibiotics, antifungal drugs, immunosuppressive drugs and hormonal drugs were investigated. And record the results of pathogen culture, treatment options, site of infection, mycological efficacy and so on. [Results] According to the results of bacterial culture and drug susceptibility test, all the cases were diagnosed as complicated fungal infection and were treated with antifungal therapy after diagnosis. Analysis found that chemotherapy, antibiotic treatment, immunosuppressive agents are the risk factors for fungal infections in patients with blood diseases. [Conclusion] Patients with hematological diseases are faced with many risk factors of fungal infection, with complicated pathogens and multiple sites of infection.