利用一肾一夹容量型和两肾一夹压力型大鼠肾血管性高血压所敛心肌肥厚及高血压逆转肥厚逆转模型,测定血浆、心房和心审心钠素水平。发现两型高血压大鼠血浆及左室的心钠素水平明显增高,左室及血浆心钠素浓度与相对室重呈正相关,左房心钠素浓度在一肾一夹型明显降低;随着高血压的逆转,两型大鼠血浆及心房心钠素水平基本恢复,增高了的心室心钠素由高水平下降。结果提示。在高血压、容量扩张并伴有心肌肥厚的病理情况下,心室心钠素可能起重要的代偿调节作用。 The levels of atrial natriuretic peptide, atrial natriuretic peptide and atrial natriuretic peptide in atrial natriuretic peptide and atrial natriuretic peptide were measured by using a model of renal volume and renal hypertensive rats with hypertensive renal hypertensive rats. Found that two types of hypertension in plasma and left ventricular atrial natriuretic peptide levels were significantly increased, left ventricular and plasma atrial natriuretic peptide concentration and relative ventricular weight was positively correlated, atrial natriuretic peptide concentration in a kidney a folder type was significantly reduced; The reversal of hypertension, two types of rats plasma and atrial natriuretic peptide levels recovered, increased ventricular atrial natriuretic peptide levels from high to low. The results suggest. Ventricular atrial natriuretic peptide may play an important compensatory role in the pathogenesis of hypertension, volume expansion and concomitant cardiac hypertrophy.