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目的 探讨血管内皮生长因子 (VEGF)在贲门癌中的表达及其与临床特征之间的关系。方法 应用免疫组化法检测 6 4例贲门癌组织中VEGF的表达 ,并对血管进行八因子相关抗原的免疫组化染色计数。结果 6 4例贲门癌组织中 ,VEGF阳性表达率为 6 2 5 % (40 / 6 4)。高水平的VEGF表达与肿瘤的浸润性生长、浆膜浸润、淋巴结转移和其它器官转移具有明显的相关关系。VEGF表达阳性肿瘤的MVC明显高于阴性者 (P <0 0 5 )。而且随着VEGF表达强度的增强 ,癌组织内血管密度明显增加。结论 VEGF与贲门癌的生长、浸润和淋巴结转移密切相关 ,是贲门癌主要的新生血管诱导因子之一 ,可促进贲门癌的血管生成 ,对贲门癌组织中VEGF的检测将可能成为贲门癌预后的一个有用指标 ,以用于识别高危转移和不良预后者
Objective To investigate the expression of vascular endothelial growth factor (VEGF) in cardia cancer and its relationship with clinical features. Methods Immunohistochemistry was used to detect the expression of VEGF in 64 cases of cardia carcinoma and the immunohistochemical staining of eight factors related to blood vessels was performed. Results Among 64 cases of cardia cancer, the positive expression rate of VEGF was 62.5% (40/64). High levels of VEGF expression and invasive growth of the tumor, serosal invasion, lymph node metastasis and other organ metastases have a clear correlation. The MVC of VEGF-positive tumors was significantly higher than that of negative ones (P <0.05). And with the enhanced expression of VEGF, vascular density within the cancer tissue increased significantly. Conclusions VEGF is closely related to the growth, infiltration and lymph node metastasis of gastric cardia carcinoma. It is one of the main angiogenesis inducing factors of cardia carcinoma and can promote the angiogenesis of gastric cardia carcinoma. The detection of VEGF in gastric cardia carcinoma may become the prognosis of gastric cardia carcinoma A useful indicator for identification of high-risk metastases and poor prognosis