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目的 :了解胃癌在不同的发生阶段 ,机体血清 SOD活力及铜、锌含量的变化。方法 :应用亚硝酸盐法、比色法分别测定了胃癌癌变过程各阶段人群的血清 SOD和铜、锌含量。结果 :随着胃粘膜上皮细胞病变的进程 ,1在胃癌癌变过程中机体活性 Cu Zn SOD呈逐渐下降趋势 ,经方差分析五组间有显著性差异 (P <0 .0 1) ,2机体血清 Cu含量呈明显升高趋势 ,尤以癌症组为甚 ,而血清 Zn含量则随病变进展而显著下降经方差分析五组间有显著性差异 (P <0 .0 5 )。结论 :胃部的发生发展与机体氧化 /抗氧化状态的失衡有密切联系 ,表现为机体氧化应激损伤的亢奋状态和抗氧化能力的减弱。Cu和 /或Zn的缺乏 ,导致 Cu Zn SOD活力下降 ,可能是胃癌发生发展的另一生化机制。
Objective: To understand the changes of serum SOD activity and copper and zinc levels in different stages of gastric cancer. Methods : Serum SOD, copper, and zinc levels were determined by nitrite method and colorimetry method respectively at the various stages of gastric carcinogenesis. Results: With the progress of epithelial cell lesions in the gastric mucosa, 1 the activity of Cu Zn SOD in the gastric carcinogenesis gradually decreased, and there was a significant difference between the five groups by analysis of variance (P < 0.01). The Cu content increased significantly, especially in the cancer group, while the serum Zn content decreased significantly with the progression of the disease. There was a significant difference between the five groups analyzed by variance (P < 0.05). Conclusion: The occurrence and development of the stomach are closely related to the imbalance of the body’s oxidative/antioxidative state, manifested by the oxidative stress of the body in the excitement state and weakened antioxidant capacity. The lack of Cu and/or Zn leads to a decrease in Cu Zn SOD activity, which may be another biochemical mechanism for the development of gastric cancer.