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目的观察白大衣高血压(white coat hypertension,WCH)患者血清中肿瘤坏死因子-α(Tumor necrosis factor-α,TNF-α)、白细胞介素-6(interleukin-6,IL-6)、丙二醛(malondialdehyde,MDA)、超氧化物歧化酶(superoxide dismutase,SOD)水平和颈动脉内膜中层厚度(intima-media thickness,IMT),评价其临床意义。方法研究对象90例,分为白大衣高血压组(A组,n=30),非白大衣高血压组(B组,n=30)及健康对照组(C组,n=30);以多普勒超声测定IMT值,检测、比较各组间TNF-α、IL-6、MDA、SOD、IMT水平。结果三组患者TNF-α、IL-6、MDA、IMT水平B组高于A组(P<0.05或P<0.01),A组高于C组(P<0.01);而SOD水平C组高于A组(P<0.01),A组高于B组(P<0.01)。结论白大衣高血压患者血清细胞因子TNF-α、IL-6、MDA、SOD水平及颈动脉内膜中层厚度及介于EH者与正常血压者之间,反映白大衣高血压时机体已产生免疫调节与自身保护,并且引起靶器官的损害,提示白大衣高血压是介于高血压与正常血压之间的临床状态,应视为原发性高血压(Essential hypertension,EH)早期的表现之一,应受到重视。
Objective To observe the changes of serum tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and malondialdehyde (2) in white coat hypertension (WCH) The levels of malondialdehyde (MDA), superoxide dismutase (SOD) and carotid artery intima-media thickness (IMT) were measured to evaluate the clinical significance. Methods 90 subjects were divided into white coat hypertension group (group A, n = 30), non-white coat hypertension group (group B, n = 30) and healthy control group (group C, n = 30) Doppler ultrasound was used to measure the IMT value. The levels of TNF-α, IL-6, MDA, SOD and IMT in each group were detected and compared. Results The levels of TNF-α, IL-6, MDA and IMT in three groups were higher than those in group A (P <0.05 or P <0.01), those in group A were higher than those in group C (P <0.01) In group A (P <0.01), group A was higher than group B (P <0.01). Conclusions The serum levels of TNF-α, IL-6, MDA, SOD and carotid artery intima-media thickness in white coat hypertensive patients and those between EH and normal blood pressure reflect the body’s immune system Regulate and protect themselves, and cause damage to target organs, suggesting that white coat hypertension is a clinical condition between hypertension and normotensive and should be considered as one of the early manifestations of Essential Hypertension (EH) , Should be taken seriously.