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目的硒是与抗氧化酶的活性有关的微量元素,被认为是一种通过增强酶的活性来拮抗自由基的保护剂。关于硒与阿尔茨海默病(AD=Alzheimer’s Disease,或称Dementia)的关系研究结果不一致。为此,进行了硒水平与中国农村老年人群认知能力研究。方法研究对象为中国四川和山东两省四县市的2000名≥65岁老年人群,当地出生并在当地居住。采用环境流行病学方法,调查研究了老年人群认知能力、APOE基因、指甲硒与血液硒,以及环境食物硒和老年人群日摄硒量。相关系数、方差模型和协方差多因素模型应用于硒水平与认知记分的统计分析。结果分析结果指出硒水平与老年人群认知能力二者之间有明显的正相关,并呈现剂量-反应关系。结论中国农村老年人群稳定的硒暴露水平研究,支持了终身低硒水平与低认知能力相关的假设。
Purpose Selenium is a trace element associated with the activity of antioxidant enzymes and is considered as a protective agent against free radicals by increasing the enzyme activity. The findings on the relationship between selenium and Alzheimer’s disease (AD = Alzheimer’s Disease, or Dementia) are inconsistent. To this end, the level of selenium and Chinese rural elderly cognitive ability study. Methods The study population was 2000 ≥65-year-old elderly population in four counties and cities in Sichuan and Shandong provinces of China, where they were born and lived in the area. Using environmental epidemiological methods, we investigated the elderly people’s cognitive ability, APOE gene, fingernail selenium and blood selenium, as well as environmental food selenium and elderly people’s daily photogenic selenium. Correlation coefficient, variance model and covariance multi-factor model were applied to the statistical analysis of selenium level and cognitive score. The results of the analysis indicated that there was a significant positive correlation between the level of selenium and the cognition of the elderly, and the dose-response relationship. Conclusions Stable selenium exposure levels in the elderly in rural China support the hypothesis that lifelong low selenium levels are associated with low cognitive abilities.