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Moschcowitz(1924)观察到1例发热、紫癜、贫血和镜下血尿的16岁女性患者,发病13天后死亡。尸检时镜检发现,终未小动脉和毛细血管中广泛存在着被纤维母细胞包裹的透明样血栓,推测是由一种具有极强聚集血小板和溶血作用的毒素导致红细胞凝集和透明化样作用。Baehr等(1936)在4例有严重的进行性贫血和血小板减少的9—48岁女性患者中,观察到微血栓周围的纤维母细胞被增殖的内皮细胞所覆盖。形态学观察和姬姆萨染色表明血栓由纤维蛋白和凝聚的血小板组成,提示本病患者存在着广泛的血管损害。1947年该病被Singer等定名为血栓性血小板减少性紫癜(TTP)。Bernheim等称之为Moschcowi-tz’s病。
Moschcowitz (1924) observed a 16-year-old woman with fever, purpura, anemia, and microscopic hematuria who died 13 days after onset. Microscopic examination at necropsy revealed a widespread presence of fibrinoblast-like, clear-like thrombi in the terminal arterioles and capillaries presumably by a toxin that agglutinates platelets and hemolysis and causes hemagglutination and opacification . Baehr et al. (1936) observed that in four women aged 9-48 years with severe progressive anemia and thrombocytopenia, fibroblasts surrounding the microthrombus were covered with proliferating endothelial cells. Morphological observation and Giemsa staining indicate that thrombus consists of fibrin and aggregated platelets, suggesting extensive vascular damage in this patient. In 1947 the disease was named Singer et al thrombotic thrombocytopenic purpura (TTP). Bernheim and others call it Moschcowi-tz’s disease.