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目的 寻找垂体腺瘤术后复发的相关因素。方法 随机选择经 10～ 2 0年随访证实术后复发和未复发的病人各 45例 ,对两组病人的临床资料和肿瘤细胞的增殖指数两方面数据作差异显著性检验。结果 在临床表现方面 ,肿瘤大小 ,是否手术全切除 ,肿瘤组织有无坏死、囊变、卒中、鞍外扩展 ,两组有显著差异 (P <0 0 5 ) ,肿瘤细胞的增殖细胞核抗原 (PCNA)及Ki 6 7核抗原表达指数两组也有显著差异 (P <0 0 5 )。结论 肿瘤细胞的增殖核抗原表达指数对判断垂体腺瘤的手术预后是客观而准确的指标之一 ,有临床指导意义
Objective To find out the related factors of postoperative recurrence of pituitary adenoma. Methods A total of 45 patients with postoperative recurrence and non-recurrence were randomly selected from 10 to 20 years of follow-up. The clinical data of two groups and the proliferation index of tumor cells were statistically analyzed. Results In terms of clinical manifestations, tumor size, total resection volume, tumor necrosis, cystic degeneration, stroke and extracranial expansion were significantly different between the two groups (P <0.05), PCNA ) And Ki 6 7 nuclear antigen expression index were also significantly different between the two groups (P <0 05). Conclusion Proliferating cell nuclear antigen expression index of tumor cells is an objective and accurate indicator for judging the surgical prognosis of pituitary adenoma and has clinical significance