目的　评价三种不同介入方法治疗兔VX -2肝肿瘤的疗效和副反应。方法　 2 4只实验兔分为三组 ,单纯灌注化疗组 7只、化疗性栓塞组 8只、生理盐水治疗组 9只 ,实验均采用经兔股动脉肝动脉插管方法。分别于介入术前、术后 1周、术后 2周行兔肝肿瘤螺旋CT扫描 ,测量肿瘤大小并观察肿瘤变化情况 ,计算不同介入方法治疗后肿瘤的增长率。 2周后行兔肝脏病理检查 ,比较肿瘤生长、肺转移和周围正常肝组织的情况。结果　单纯灌注化疗组、化疗性栓塞组、生理盐水对照组术后 1周平均肿瘤增长率分别为 90 .88%、75 .45 %、3 5 0 .96%。术后 2周平均肿瘤增长率分别为 2 83 .49%、2 3 7.99%、845 .43 %。 2周后化疗栓塞组兔肿瘤周围炎性细胞浸润和周围肝组织缺血情况明显高于其余 2组 ,肝内肿瘤播散结节和肺转移结节明显少于其余 2组 ,统计学比较有明显差异 (Ρ <0 .0 5 )。结论　在肝癌的介入治疗中 ,单纯化疗有一定的疗效 ,带化疗药物的碘油等栓塞剂的使用可进一步提高疗效。碘油等栓塞剂对正常肝组织有损害作用 ,应避免或减少其进入正常肝组织。 Objective To evaluate the efficacy and side effects of three different interventional methods for treatment of rabbit VX-2 liver tumors. Methods Twenty-four experimental rabbits were divided into three groups: 7 infusion only chemotherapy group, 8 chemotherapy-induced embolization group, and 9 saline-treated group. All rabbits were treated with hepatic artery catheterization through femoral artery. Spiral CT scans of rabbit liver tumors were performed before interventional surgery, one week after surgery, and two weeks after operation. The tumor size was measured and observed for tumor changes. The growth rate of tumors after different interventional methods was calculated. Rabbit liver pathology was performed 2 weeks later to compare tumor growth, lung metastasis, and surrounding normal liver tissue. Results The average tumor growth rate in the single-infusion chemotherapy group, the chemotherapy embolization group, and the saline control group was 90.88%, 75.45%, and 35.96%, respectively. The average tumor growth rate at 2 weeks after surgery was 2 83.49%, 2 3 7.99%, and 845.44%, respectively. After 2 weeks, peritumoral inflammatory cell infiltration and surrounding liver tissue ischemia in the chemoembolization group were significantly higher than those in the other two groups. The disseminated nodules and metastatic lung nodules in the intrahepatic tumor were significantly less than those in the other two groups. Significant differences (Ρ < 0.55). Conclusion In the interventional treatment of liver cancer, chemotherapy alone has a certain effect, and the use of lipiodol and other embolic agents with chemotherapeutic drugs can further improve the curative effect. Lipiodol and other embolic agents have a damaging effect on normal liver tissue and should be avoided or reduced into normal liver tissue.