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一、肾小球免疫沉积物形成的机理 大多数免疫肾病与IgG和补体在肾小球的沉积有关。目前,免疫肾病分为抗肾小球基底膜(GBM)型和免疫复合物型。线型和球型的免疫沉积物均为抗体与内源性肾小球抗原的结合物。球型沉积物也是由于抗体通过几种不同的方式与肾小球局部定位的抗原结合以及捕获循环免疫复合物所致。
First, the mechanism of the formation of glomerular immune deposits Most immune nephropathy and IgG and complement deposition in the glomerular. At present, immune kidney disease is divided into anti-glomerular basement membrane (GBM) type and immune complex type. Both linear and globular immunoprecipitates are conjugates of antibodies with endogenous glomerular antigens. Globular deposits are also due to antibodies that bind to antigens locally localized by glomeruli and capture circulating immune complexes in several different ways.