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目的观察IGR患者血清血红素氧化酶-1(HO-1)、颈动脉内-中膜厚度(CIMT)及斑块形成情况,探讨HO-1在IGR伴或不伴动脉粥样硬化(AS)患者中的变化及影响因素。方法选取IGR者199例,接受颈动脉超声检测,根据病变性质分为颈动脉正常(CIMT≤0.9mm)组124例和颈动脉斑块形成(CIMT≥1.5mm,或有斑块形成)组75例,另设对照(NGT)组62名。ELISA检测血清HO-1水平。结果颈动脉正常组和颈动脉斑块形成组HO-1水平高于NGT组,且颈动脉斑块形成组高于颈动脉正常组(P<0.05);Spearman相关分析显示,HO-1水平与SUA、TC、LDL-C、BMI呈正相关(r=0.126、0.204、0.187、0.207,P=0.042、0.001、0.003、0.002);多元逐步回归分析显示,HOMA-IR、TC、CIMT是HO-1的危险因素(β=50.05、26.16、572.68,P=0.000、0.007、0.001);Logistic回归分析发现,HO-1为颈动脉粥样硬化的保护因素(OR=0.990,95%CI:0.981~0.999,P=0.000)。结论 IGR患者检测血清HO-1水平可能有益于发现高AS患病风险者。
Objective To observe the changes of serum heme oxygenase-1 (HO-1), carotid artery intima-media thickness (CIMT) and plaque formation in patients with IGR and to explore the relationship between HO-1 and IGR with or without atherosclerosis (AS) Patients in the changes and influencing factors. Methods One hundred and fourty-nine patients with IGR were selected and underwent carotid ultrasonography. According to the nature of the disease, 124 patients with normal carotid artery (CIMT≤0.9mm) and 75 patients with carotid plaque (CIMT≥1.5mm or plaque formation) For example, there are 62 control groups (NGT). ELISA detection of serum HO-1 levels. Results The level of HO-1 in normal carotid artery and carotid plaque formation group was higher than that in NGT group, and carotid artery plaque formation group was higher than normal carotid artery group (P <0.05). Spearman correlation analysis showed that HO-1 level and SUA, TC, LDL-C and BMI (r = 0.126,0.204,0.187,0.207, P = 0.042,0.001,0.003,0.002). Multiple stepwise regression analysis showed that HOMA-IR, TC and CIMT were HO- (Β = 50.05,26.16,572.68, P = 0.000,0.007,0.001). Logistic regression analysis showed that HO-1 was the protective factor of carotid artery atherosclerosis (OR = 0.990, 95% CI: 0.981-0.9999) , P = 0.000). Conclusions Detection of serum HO-1 levels in patients with IGR may be useful in detecting patients with high AS risk.