论文部分内容阅读
[背景]颗粒物和靠近大型公路可促进疾病的发展,包括全身炎症、内分泌改变和血管增生,这可能会导致子宫内膜异位症的发生和恶化。[目的]确定成年期空气污染暴露,包括与道路的距离、<2.5μm、2.5~10μm,和<10μm的颗粒物(PM2.5、PM10-2.5、PM10)以及暴露时机,与护士健康研究II中子宫内膜异位症风险间的相关性。[方法]测定1993—2007年所有住址至主要公路的距离以及室外PM2.5、PM10-2.5和PM10水平。用多变量调整的时变Cox比例风险模型来估计这些空气污染暴露与子宫内膜异位症风险之间的关系。[结果]在84 060位妇女中,随访超过710,230人年,手术证实的子宫内膜异位症有2486例。没有证据表明在子宫内膜异位症的风险与至道路的距离或随访期间或前2、4年平均的PM2.5、PM10-2.5或PM10暴露之间存在相关性。[结论]成年期中交通和空气污染暴露与此妇女队列中子宫内膜异位症的发生不相关。
[Background] Particulate matter and proximity to large highways can promote disease development, including systemic inflammation, endocrine changes and vascular proliferation, which may lead to the occurrence and worsening of endometriosis. [Objective] To determine the air pollution exposure in adulthood, including the distance to the road, PM2.5, PM10-2.5, PM10 <2.5μm, 2.5 ~ 10μm, and <10μm and the timing of exposure, Correlation between the risk of endometriosis. [Method] The distances from all the sites to the main road from 1993 to 2007 and the outdoor PM2.5, PM10-2.5 and PM10 levels were measured. The multivariate adjusted time varying Cox proportional hazards model was used to estimate the relationship between these air pollution exposures and the risk of endometriosis. [Results] Of the 84 060 women who followed over 710,230 person-years, there were 2486 cases of endometriosis confirmed by surgery. There is no evidence that there is a correlation between the risk of endometriosis and the average distance between PM2.5, PM10-2.5 or PM10 exposures to the road to or during the follow-up or to the previous 2-4 years. [Conclusion] The traffic and air pollution exposure in adulthood is not related to the occurrence of endometriosis in this woman cohort.