衰竭心肌的结构发生一系列的改变,其中最主要的是心肌细胞的肥大和细胞外诸种基质蛋白的增加,常表现为原发性纤维化。结缔组织生长因子(CTGF)是纤维化过程中的一个关键性因子,因此被视为具有吸引力的治疗目标。学者们对驱动子水平上的CTGF表达的调节进行过大量的研究,但在转录 A series of changes in the structure of failing myocardium, of which the most important is the hypertrophy of cardiomyocytes and extracellular matrix proteins increase, often manifested as primary fibrosis. Connective tissue growth factor (CTGF) is a key factor in fibrosis and is therefore considered as an attractive therapeutic target. Scholars have done a lot of research on the regulation of CTGF expression at the level of the driver, but in transcription