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应用6周龄的白鼠注射内毒素（E．coli0111：B4）的方法以评价胃肠通过时间，肌酐清除率，双糖（乳果糖、甘露醇）的肠道通透性。给予~（51）铬－依地酸动态监测通过消化道时间表明，内毒素组胃排空时间比生理盐水对照组明显延长（t1／2＝26±2vs162±20minP＜0．01），小肠运行时间无明显改变（81±17vs93±29min）。通过尿中乳果糖／甘露醇排泄比来评定肠通透性，内毒素组通透性比对照组高（1．01±0．08vs0．60±0．04P＜0．01）。在测试期测定小肠有效吸收标记物数量以校正个别糖排泄后，结果是内毒素可使乳果糖吸收增加，但甘露醇吸收无改变。本研究也提示内毒素血症（通过药物或其它治疗后无并发症）能使胃排空时间明显延长，于是影响到口服或鼻胃管喂养的耐受性。
Six-week-old white mice were injected with endotoxin (E.coli0111: B4) to assess gastrointestinal transit time, creatinine clearance, and intestinal permeability of disaccharides (lactulose, mannitol). Dynamic monitoring of ~ (51) Chromium-edetic acid showed that the gastric emptying time in the endotoxin group was significantly longer than that in the saline control group (t1 / 2 = 26 ± 2 vs162 ± 20minP <0.01) No significant change in time (81 ± 17 vs 93 ± 29 min). Intestinal permeability was assessed by urinary lactulose / mannitol excretion ratio (1.01 ± 0.08 vs 0.60 ± 0.04 P <0.01). Determination of the number of effective intestinal absorption markers to correct individual sugar excretion during the test period resulted in increased lactulose uptake but no change in mannitol uptake. This study also suggests that endotoxemia (no complications after drug or other treatment) significantly prolongs gastric emptying and therefore affects oral or nasogastric tube feeding tolerance.