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目的 :比较特比萘芬软膏和咪康唑软膏治疗浅部真菌病的疗效。方法 :特比萘芬组 80例 (男性 4 2例 ,女性 38例 ;年龄 4 2a±s 2 1a)手、足癣病人 4 0例 ,疗程 2wk ;体、股癣病人 4 0例 ,疗程 1wk。咪康唑组 6 0例 (男性 2 9例 ,女性 31例 ;年龄 4 2a±19a)手、足癣病人 30例 ,疗程 4wk ;体、股癣病人30例 ,疗程 2wk ,2组均每日 2次分别外用特比萘芬软膏和咪康唑软膏。结果 :特比萘芬组有效率停药时为 84 % (6 7/ 80 ) ,停药 2wk后为 92 % (74 / 80 ) ;咪康唑组停药时为 58% (35/ 6 0 ) ,停药 2wk后为53% (32 / 6 0 ) ,2组差异有显著意义 (P <0 .0 5)。真菌清除率停药 2wk后特比萘芬组为 94 % (35/ 80 ) ,咪康唑组为 6 8% (4 1/ 6 0 ) ,2组差异有非常显著意义(P <0 .0 1)。结论 :特比萘芬软膏治疗浅部真菌病较咪康唑软膏疗程短、疗效好
OBJECTIVE: To compare the efficacy of terbinafine ointment and miconazole ointment in the treatment of superficial mycosis. Methods: Eighty patients (42 males and 38 females; age 4 2a ± s 2 1a) were treated with terbinafine, 40 cases of tinea pedis, 2 weeks of treatment and 40 cases of tinea corporis and tinea corporis. The course of treatment was 1 wk . Miconazole group 60 cases (29 males and 31 females; age 4 2a ± 19a) hand and foot ringworm patients in 30 cases, 4wk treatment; body, tinea cruris in 30 patients, treatment 2wk, 2 groups were daily 2 times were topical terbinafine ointment and miconazole ointment. Results: The effective rate in terbinafine group was 84% (67/80) after discontinuation of treatment, 92% (74/80) after 2 weeks of withdrawal, and 58% (35/60) in miconazole group ), And 53% (32/60) after 2 weeks of withdrawal. There was significant difference between the two groups (P <0.05). The fungal clearance rate was 94% (35/80) in the terbinafine group and 68% (4 1/60) in the miconazole group after 2 weeks of withdrawal, with significant differences between the 2 groups (P <0. 0 1). Conclusion: Terbinafine ointment is superior to miconazole ointment in the treatment of superficial mycosis