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目的:探讨彩色多普勒超声在诊断三阴性乳腺癌(TNBC)中的应用价值。方法:169例经彩色多普勒超声诊断乳腺占位性病变,并经手术和病理检查确诊为乳腺癌的患者,根据免疫组织化学染色检测雌激素受体(ER)、孕激素受体(PR)和人表皮生长因子受体2(HER2)表达情况,分为TNBC组37例和非TNBC组132例,分析比较2组的超声声像图、病理及临床情况。结果:与非TNBC组比较,TNBC组肿块有较清楚边界的比例高(P<0.05),病灶边缘毛刺状的比例低(P<0.05),病灶内部回声较低且较少钙化(P<0.01),病灶后方声影较少衰减(P<0.05),病灶内无血流或较少血流(P<0.05),血流阻力指数<0.7的比例高(P<0.05)。TNBC组腋窝淋巴结转移高于非TNBC组(P<0.05)。结论:TNBC在超声声像图上的表现更倾向于良性肿块。彩色多普勒超声检查在诊断TNBC方面可起到早期诊断或早期提示作用。
Objective: To explore the value of color Doppler ultrasound in the diagnosis of triple negative breast cancer (TNBC). Methods: A total of 169 patients with breast lesions diagnosed by color Doppler ultrasonography were diagnosed as breast cancer by operation and pathology. The expressions of estrogen receptor (ER), progesterone receptor (PR) ) And human epidermal growth factor receptor 2 (HER2) were divided into 37 cases of TNBC group and 132 cases of non-TNBC group. The sonography, pathology and clinical situation of the two groups were analyzed. Results: Compared with non-TNBC group, TNBC group had a higher proportion of clear border (P <0.05), lesser burr edge ratio (P <0.05), lesser internal echo and less calcification (P <0.01) ). The acoustic attenuation in the posterior lesion was less attenuated (P <0.05). There was no blood flow or less blood flow in the lesion (P <0.05). The ratio of the blood flow resistance index <0.7 was higher (P <0.05). Axillary lymph node metastasis in TNBC group was higher than that in non-TNBC group (P <0.05). CONCLUSIONS: The performance of TNBC on ultrasonography is more likely to be benign. Color Doppler ultrasound in the diagnosis of TNBC can play an early diagnosis or early warning role.