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[目的]探讨肌钙蛋白Ⅰ和脑钠肽评估蒽环类药物对心脏的早期毒性的价值。[方法]对2013年3月至2014年10月收治50例肿瘤患者,化疗方案以静脉滴注表阿霉素为主,表阿霉素总累积量300±75mg/m2,于化疗前及化疗结束后检测血浆肌钙蛋白Ⅰ和脑钠肽含量。[结果 ]全组患者中发生心脏毒性8例,发生心脏毒性患者化疗前肌钙蛋白Ⅰ和脑钠肽水平均无心脏毒性组升高,且具有统计学意义(P<0.05)。[结论]在监测表阿霉素心脏毒性上,肌钙蛋白Ⅰ和脑钠肽能较早期反映心脏损害。
[Objective] To investigate the value of troponin I and brain natriuretic peptide in assessing the early toxicity of anthracyclines to heart. [Methods] From March 2013 to October 2014, 50 patients with cancer were treated. Epirubicin was the main chemotherapy regimen. The total cumulative amount of epirubicin was 300 ± 75 mg / m2. Before chemotherapy and chemotherapy After the end of the test, plasma troponin I and brain natriuretic peptide content. [Results] All patients had cardiotoxicity in 8 cases. The levels of troponin I and brain natriuretic peptide in patients with cardiotoxicity were not increased in the group of cardiotoxicity before chemotherapy and were statistically significant (P <0.05). [Conclusion] Cardiac troponin Ⅰ and brain natriuretic peptide can reflect heart damage earlier than epirubicin cardiotoxicity.