论文部分内容阅读
胰岛素抵抗和β细胞功能缺陷是2型糖尿病发病的主要机制。以往根据胰岛素放射免疫法(RIA)测定结果认为2型糖尿病患者具有高胰岛素血症,实际RIA法测定的是胰岛素、胰岛素原及其中间代谢产物的总水平而不是真正胰岛素水平。近来采用双位点夹心放大酶联免疫分析法测定,发现肥胖的2
Insulin resistance and beta cell dysfunction are the major pathogens of type 2 diabetes. In the past, patients with type 2 diabetes mellitus had hyperinsulinemia on the basis of the results of radioimmunoassay (RIA). The actual RIA method was to determine the total level of insulin, proinsulin and their intermediate metabolites instead of the true insulin level. Recently, a double-site sandwich enzyme-linked immunosorbent assay was used to detect obesity.2