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目的:观察常规西药治疗基础上加用肾康注射液及血栓通注射液治疗早期糖尿病肾病的临床疗效。方法:选取80例早期糖尿病肾病患者,以数字表格法分为治疗组与对照组各40例,对照组常规治疗,治疗组在常规治疗基础上加用肾康注射液、血栓通注射液静脉滴注,每天1次,疗程2周,观察治疗前后血尿素氮(BUN)、肌酐(SCr)、尿微量白蛋白(MA)、β2-微球蛋白(β2-MG)变化及中医证候评分变化。结果:治疗前2组中医证候评分比较,差异无显著性意义(P>0.05),2组治疗后均较治疗前下降,与治疗前比较,差异有显著性意义(P<0.05),治疗组低于对照组,组间比较差异有显著性意义(P<0.05)。2组患者治疗前BUN、SCr、MA、β2-MG比较,差异均无显著性意义(P>0.05),2组治疗后BUN、SCr、MA指标均较治疗前下降,与治疗前比较,差异均有显著性意义(P<0.05),β2-MG治疗组治疗后较治疗前下降,与治疗前比较,差异有显著性意义(P<0.05),对照组治疗前后比较,差异无显著性意义(P>0.05),治疗后BUN、SCr、MA、β2-MG组间比较,治疗组均较对照组为低(P<0.05)。结论:肾康注射液联合血栓通注射液治疗早期糖尿病肾病能明显改善肾功能,疗效较好,值得推广。
Objective: To observe the clinical efficacy of traditional Chinese medicine plus Shenkang injection and Xueshuantong injection in the treatment of early diabetic nephropathy. Methods: Eighty patients with early diabetic nephropathy were selected and divided into treatment group and control group with 40 cases in each group. The control group received routine treatment. The treatment group was treated with Shenkang injection and Xueshuantong injection intravenously The changes of blood urea nitrogen (BUN), creatinine (SCr), urine microalbumin (MA), β2-microglobulin (β2-MG) and TCM syndrome score before and after treatment were observed. . Results: There was no significant difference in TCM syndrome score between the two groups before treatment (P> 0.05), but the difference was significant (P <0.05) between the two groups before treatment and after treatment Group lower than the control group, the difference between the groups was significant (P <0.05). There were no significant differences in BUN, SCr, MA and β2-MG between the two groups before treatment (P> 0.05). The BUN, SCr and MA indexes in both groups decreased after treatment compared with those before treatment, (P <0.05). There was a significant difference between before and after treatment in the β2-MG treatment group (P <0.05), but there was no significant difference in the control group before and after treatment (P> 0.05). After treatment, the levels of BUN, SCr, MA and β2-MG in treatment group were lower than those in control group (P <0.05). Conclusion: Shenkang injection combined with Xueshuantong injection in the treatment of early diabetic nephropathy can significantly improve renal function, with good curative effect and worthy of promotion.