Objective: To Discuss the correlation between Hypersensitivity C-reactive Protein (Hs-CRP), Total Cholesterol (TC), Triglyceride (TG), negative emotion scale and TCM syndrome scores in “Double Heart Disease” patients with Qi stagnation blood stasis and heart gallbladder heat stagnation. Method: Fifty-two patients in Western Medicine Diagnosis of Double Heart Disease, in TCM syndrome identified as Qi stagnation blood stasis Heart gallbladder heat stagnation syndrome, detects it Hs-CRP, TC, TG levels by ELISA, use TCM Syndromes Scale to evaluate TCM Syndrome, use the Pittsburgh Sleep Quality Index(PSQI) and Self-rating symptom scale(SCL-90) to assess anxiety and sleep levels, analyze the correlation between TCM syndrome scores and Hs-CRP, TC, TG level, PSQI index, SCL-90 index. Result: There was a significant positive correlation between Hs-CRP, TG level and TCM Syndrome scores(P0.05); There was a significant positive correlation between PSQI index, SCL-90 index and TCM Syndrome scores(P<0.05). Conclusion: In “Double Heart Disease” patients with Qi stagnation blood stasis and heart gallbladder heat stagnation, there have characteristic syndrome changes in terms of inflammatory factor level, blood lipid level and negative emotion score; Which the above indexes can reflect the severity of TCM syndromes to a certain extent and provide the basis for the effective intervention treatment of TCM.