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随机选择原发性高血压患者112例,其中有靶器官损害者48例,无靶器官损害者64例;另选102名健康人为对照组,进行凝血功能检查。结果是:高血压组 APTT、TT 较对照组显著缩短,Fbg,Ⅷ:C、ⅧR:Ag 显著升高(P<0.05),ATⅢ:C 显著降低。各项凝血指标:在有、无靶器官损害患者间,均无显著性差异。而高凝状态的发生率,高血压组为22.3%,对照组仅4.9%(P<0.01)。提示:原发性高血压患者血液的高凝状态有致血栓形成倾向,这种倾向可能与高血压病患者易并发一过性脑缺血、脑卒中及冠心病密切相关.
Randomly selected 112 cases of patients with essential hypertension, including 48 cases of target organ damage, no target organ damage in 64 cases; the other 102 healthy controls for the coagulation test. The results were as follows: APTT and TT in hypertension group were significantly shorter than those in control group, the levels of Fbg, Ⅷ: C and ⅧR: Ag were significantly increased (P <0.05); ATⅢ: C was significantly decreased. The indicators of coagulation: there is no significant difference between the patients with or without target organ damage. The incidence of hypercoagulable state, hypertension group was 22.3%, control group, only 4.9% (P <0.01). It is suggested that hypercoagulability in the blood of patients with essential hypertension may lead to thrombosis. This tendency may be closely related to the transient cerebral ischemia, stroke and coronary heart disease in hypertensive patients.