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骨质疏松已见于慢性维生素A过多症,但为人类维甲酸治疗的毒性反应则尚未明确。阿维A酯(E)和异维A酸(I)已广泛用于皮肤病和恶性疾病的治疗。慢性疾病患者需终身治疗增加了毒性反应的危险,合成维甲酸类的毒性反应极象Vit A过多症,如骨骺过早闭合,骨肥厚以及脊柱外肌腱和韧带钙化。Vit A在体外和动物模型中可致骨吸收和长骨骨折,在人体内有脱矿质作用。作者通过骨矿物质密度(BMD)检查评估长期使用维甲酸能否造成骨质疏松。
Osteoporosis has been seen in chronic vitamin A hyperactivity, but the toxicity of human retinoic acid treatment is not yet clear. Avermectin (E) and isotretinoin (I) have been widely used in the treatment of dermatological and malignant diseases. Life-long treatment of patients with chronic diseases increases the risk of toxic reactions. The toxic reactions of synthetic retinoids are very much like Vit A hyperactivity such as premature epiphyseal closure, hypertrophy of the bone, and extra-spinal tendon and ligament calcification. Vit A can induce bone resorption and long bone fractures in vitro and in animal models with demineralization in the human body. The authors use bone mineral density (BMD) test to assess whether long-term use of retinoic acid can cause osteoporosis.