【摘 要】
：
Leonurine(1),an important ingredient in leonurus sibiricus L,can be used for some gynecological disease.We have developed a concise and efficient synthetic rout
【机 构】
：
Anhui Engineering Technology Research Center for Extraction and Isolation of Active Components,Anhui
【出 处】
：
Chinese Chemical Letters
论文部分内容阅读
Leonurine(1),an important ingredient in leonurus sibiricus L,can be used for some gynecological disease.We have developed a concise and efficient synthetic route of Leonurine,which can be optimized for mass production.Commercially available compound 6 and 2,3-dihydrofuran(7) were used as starting materials.And the toxicity study on zebrafish shows that Leonurine would promote the hatching of zebrafish embryos at low concentration and result in acute death or chronic lethal toxicity at high concentration.
Leonurine (1), an important ingredient in leonurus sibiricus L, can be used for some gynecological disease. We have developed a concise and efficient synthetic route of Leonurine, which can be optimized for mass production. Commercially available compound 6 and 2,3- dihydrofuran (7) were used as starting materials. And the toxicity study on zebrafish shows that Leonurine would promote the hatching of zebrafish embryos at low concentration and result in acute death or chronic lethal toxicity at high concentration.
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