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目的探索真实世界中使用灯盏细辛注射液对肝功能的影响。方法选取来源自全国20家大型三甲医院的医院信息系统(hospital information system,HIS)数据中使用灯盏细辛注射液者21498例作为暴露组,选取年龄在18~80岁之间,并且使用灯盏细辛注射液前后间隔≥7 d至少有2次肝功能检测的患者1641例,提取谷草转氨酶(AST)和谷丙转氨酶(ALT)指标,采用logistic回归、不带协变量的GBM倾向评分加权logistic回归以及带协变量的GBM倾向评分加权logistic回归3种方法对比分析混杂因素,研究灯盏细辛对ALT、AST的影响。结果上述3种统计学方法分析结果 P值均小于0.05,差异有统计学意义。结论基于现有的HIS数据,灯盏细辛注射液对ALT和AST可能有影响。
Objective To explore the use of Erigeron injection in the real world on liver function. Methods A total of 21498 cases of EIS were collected from hospital information system (HIS) data of 20 large top-level hospitals in China. The age of 18 to 80 years old was selected. Simultaneously, 1641 patients with at least 2 tests of hepatic function at intervals of ≥7 days before and after injection of Xin injection were used for the extraction of AST and ALT. Logistic regression and GBM propensity score-weighted logistic regression without covariate And GBM propensity score weighted logistic regression with covariates were used to compare and analyze the confounding factors to study the effects of Erigeron Breviscapus on ALT and AST. Results The P values of the above three statistical methods were all less than 0.05, the difference was statistically significant. Conclusion Based on the available HIS data, Erigeron Breviscapus Injection may have effects on ALT and AST.