论文部分内容阅读
具有不同肾功能的99名发烧病人,测定年龄对庆大霉素的半衰期、分布容积和总体清除率的影响。其中50名病人年龄为18到64岁,庆大霉素的清除率为79.0±27.0ml/分(均数±标准差);肌酐清除率98.6±33.3ml/分;分布容积0.242±0.077升/公斤;半衰期2.63±0.90小时。其他49名老年病人年龄在65～90岁之间,庆大霉素的清除率36.9±16.3ml/分;肌酐清除率为51.2±21.2ml/分;分布容积0.244±0.102升/公斤;半衰期5.8±4.13小时。两组间除分布容积外,所有参数均有显著的差异。庆大霉素的处置特点(清除率和排泄率常数)
Ninety-nine fever patients with different renal functions were tested for the effect of age on the half-life, volume of distribution, and overall clearance of gentamicin. Fifty patients were 18 to 64 years of age and the gentamicin clearance was 79.0 ± 27.0 ml / min (mean ± SD); creatinine clearance was 98.6 ± 33.3 ml / min; volume of distribution was 0.242 ± 0.077 l / Kg; half-life of 2.63 ± 0.90 hours. Other 49 elderly patients aged 65 to 90 years, the gentamicin clearance 36.9 ± 16.3ml / min; creatinine clearance was 51.2 ± 21.2ml / min; distribution volume 0.244 ± 0.102 l / kg; half-life of 5.8 ± 4.13 hours. In addition to the distribution of volume between the two groups, all parameters were significantly different. Gentamicin treatment characteristics (clearance and excretion rate constants)