论文部分内容阅读
目的探讨给予老年顽固性心绞痛患者尼可地尔联合单硝酸异山梨酯缓释片治疗的效果。方法选取2014年4月至2016年4月90例老年顽固性心绞痛患者,将其随机分为观察组和对照组,每组45例。对照组给予单硝酸异山梨酯治疗,观察组给予尼可地尔联合单硝酸异山梨酯治疗,对比分析两组心绞痛情况、心电图状况及不良反应。结果对照组治疗总有效率为80.4%,明显低于观察组的97.8%,差异有统计学意义(P<0.05);治疗后观察组心电图改善情况明显优于对照组,差异有统计学意义(P<0.05);对照组不良反应发生率为13.3%,观察组为8.9%,两组比较差异未见统计学意义(P>0.05)。结论给予老年顽固性心绞痛患者尼可地尔联合单硝酸异山梨酯缓释片治疗效果显著,可明显改善患者的心绞痛症状,促进心电图恢复正常,且药物不良反应较为轻微。
Objective To investigate the effect of nicorandil combined with isosorbide mononitrate sustained-release tablets in elderly patients with refractory angina. Methods From April 2014 to April 2016, 90 elderly patients with refractory angina were selected and randomly divided into observation group and control group, with 45 cases in each group. The control group was given isosorbide mononitrate. The observation group was treated with nicorandil and isosorbide mononitrate. The angina pectoris condition, electrocardiogram status and adverse reactions were compared between the two groups. Results The total effective rate of the control group was 80.4%, which was significantly lower than that of the observation group (97.8%), the difference was statistically significant (P <0.05); after treatment, the improvement of electrocardiogram in the observation group was obviously better than that of the control group P <0.05). The incidence of adverse reactions in the control group was 13.3% and that in the observation group was 8.9%. There was no significant difference between the two groups (P> 0.05). Conclusion Nicorandil combined with isosorbide mononitrate sustained-release tablets in elderly patients with refractory angina can significantly improve the symptoms of angina, promote normal electrocardiogram recovery, and have mild adverse drug reactions.