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目的 :观察牛磺酸对马兜铃肾损害的治疗作用 ,并探讨其机制。 方法 :给大鼠喂服马兜铃煎剂及马兜铃煎剂加牛磺酸溶液 ,观察对比血压 (尾部收缩压 ) ,SCr,BUN ,血、尿渗透压 ,血色素 ,尿蛋白SDS PAGE电泳以及肾组织脂质过氧化物 丙二醛 (Malondialdehyde ,MDA)含量、肾组织的病理改变。 结果 :四月后单服马兜铃组大鼠血清尿素氮、肾组织中MDA高于马兜铃加牛磺酸组 (P <0 0 0 2 ;P <0 0 0 5 ) ,但全血血红蛋白含量、体重较低 (P <0 0 2 ;P <0 0 2 ) ;马兜铃加牛磺酸组大鼠肾组织的病理损害较轻。 结论 :口服牛磺酸能够减轻马兜铃引起的大鼠肾脏损害 ,并维持了较好的营养状态
Objective: To observe the therapeutic effect of taurine on kidney damage in Aristolochia and to explore its mechanism. METHODS: Rats were fed with Aristolochia decoction and Aristolochia decoction plus taurine solution to observe the relative blood pressure (tail systolic blood pressure), SCr, BUN, blood, urine osmotic pressure, hemoglobin, urinary protein SDS PAGE electrophoresis As well as renal tissue lipid peroxide malondialdehyde (MDA) content, pathological changes in renal tissue. RESULTS: Serum urea nitrogen and MDA in kidney tissue of aristolochic group were higher than those of aristolochic plus taurine group (P <0 0 2; P <0 0 05), but whole blood The content of hemoglobin and body weight were lower (P <0 0 2 ; P <0 0 2 ). The pathological damage of kidney tissue in the rats of the aristolochic plus taurine group was lighter. Conclusion : Oral taurine can reduce the damage of rat kidney caused by Aristolochia and maintain a good nutritional status