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目的观察萘夫西林联合美罗培南治疗小儿化脓性脑膜炎的临床效果。方法以化脓性脑膜炎患儿88例作为研究对象,随机分为观察组和对照组,每组44例。对照组予以美罗培南单药治疗,观察组采取萘夫西林联合美罗培南的治疗方案。将2组患儿治疗前后血浆及脑脊液中的一氧化氮水平、硫化氢水平以及各项症状、实验室指标恢复正常的时间进行比较。结果治疗后,观察组血浆及脑脊液中的一氧化氮、硫化氢水平均明显低于对照组(P<0.01);观察组颅内压降低、止惊、退热、脑脊液白细胞恢复和血液白细胞恢复时间均明显短于对照组(P<0.01)。结论小儿化脓性脑膜炎采用萘夫西林联合美罗培南治疗有利于各项体征及实验室指标早日恢复至正常水平,促进患儿早日康复。
Objective To observe the clinical effect of nafcillin combined with meropenem in the treatment of purulent meningitis in children. Methods 88 cases of purulent meningitis in children as research object, were randomly divided into observation group and control group, 44 cases in each group. The control group was treated with Meropenem monotherapy, and the observation group was treated with nafcillin combined with Meropenem. The levels of nitric oxide in plasma and cerebrospinal fluid (CSF), hydrogen sulfide (H 2 S) level and symptoms and laboratory parameters returned to normal before and after treatment in two groups were compared. Results After treatment, the levels of nitric oxide and hydrogen sulfide in the plasma and cerebrospinal fluid of the observation group were significantly lower than those in the control group (P <0.01). The intracranial pressure, anticonvulsant, fever, cerebrospinal fluid leucocyte recovery and blood leukocyte recovery Time were significantly shorter than the control group (P <0.01). Conclusion The treatment of pediatric purulent meningitis with nafcillin combined with meropenem is beneficial to the early recovery of various signs and laboratory indicators to normal levels and promote the early recovery of children.