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采用彗星试验和微核试验,协同探索了五氯酚钠(Na-PCP)、二(口恶)(口英)类物质联合作用对血吸虫病流行区和正常生活区的人体外周血淋巴细胞影响效应.结果表明,实际用药区居民的外周血淋巴细胞以及用五氯酚钠与二(口恶)(口英)类物质联合作用处理过的正常人外周血淋巴细胞,其彗星率与微核率均高于对照组,在一定浓度范围内有剂量效应关系;基本的联合毒性作用推测为Na-PCP中的杂质PCDs与PCDFs等多种化学物质会损伤人体外周血淋巴细胞的DNA,其毒性作用比单一的二(口恶)(口英)类物质作用强.
The effects of sodium pentachlorophenate (Na-PCP) and dioxins on the peripheral blood lymphocytes of schistosomiasis endemic areas and normal living areas were investigated using comet assay and micronucleus test The results showed that the peripheral blood lymphocytes of residents in the actual drug-use area and the peripheral blood lymphocytes of normal people treated with sodium pentachlorophenol and dioxin (oral English) The rate was higher than the control group, in a certain concentration range dose-effect relationship; the basic joint toxicity speculated that the impurities in Na-PCP PCDs and PCDFs and other chemicals will damage human peripheral blood lymphocyte DNA, its toxicity The effect than a single two (evil) (oral English) material strong role.