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:一次颈部皮下给予海人酸 (Kainic acid,KA ,10 m g/ kg)诱发 SD大鼠出现急性癫痫发作后 ,将实验组动物随机分为 3组 ,每天灌胃分别给予生理盐水、微生态调节剂 [活菌数 4× 10 9个 (0 .4ml)只 ]和蝎毒粗提液 (SV,10 0 mg/ kg)。 10天后再次给予同样剂量的 KA检测癫痫敏感性 ,行为结果经统计学处理后表明 ,两者均可明显抑制动物癫痫敏感性的形成。免疫组化结果表明 ,两者均可防止海马硬化的形成。本工作进一步探讨了微生态调节剂与蝎毒抗癫痫作用的关系
: After an acute seizure in SD rats induced by subcutaneous injection of kainic acid (KA, 10 mg/kg), the animals in the experimental group were randomly divided into 3 groups. The rats were given normal saline and microecology respectively. Regulators [viable count 4 x 10 9 (0.4 ml) only] and venom crude extract (SV, 100 mg/kg). After 10 days, the same dose of KA was administered again to test the sensitivity of epilepsy. Statistical analysis of behavioral results showed that both can significantly inhibit the development of epilepsy sensitivity in animals. Immunohistochemistry results showed that both can prevent the formation of hippocampal sclerosis. This work further explored the relationship between microecological regulators and anti-epileptic effects of scorpion venom.