本文报道六甲蜜胺（ＨＭＭ）、长春新硷（ＶＣＲ）、强的松（Ｐｒｅｄ）（ＨＯＰ）方案治疗２５例多发性骨髓瘤（ＭＭ）的疗效，ＨＭＭ４００ｍｇ／ｄ，分４次口服，２１天为一疗程，间歇２１天，ＶｃＲ１～２ｍｇ于治疗第２１天及间歇期第１１天各一次，Ｐｒｅｄ２０ｍｇ，分次与ＨＭＭ同服，６～８个疗程为全疗程，结果：部分缓解４０％，进步４０％，有效率８０％，２３例平均生存期４２个月（４．５～１５８个月），中位生存期２８个月。作者认为ＨＯＰ可作为治疗ＭＭ有效方案之一，治疗期应密切随访血象。 This article reports the treatment of 25 cases of multiple myeloma (HM) with HMM, VCR and HOP. HMM 400mg / d, 4 times orally, 21 days For a course of treatment, intermittent 21 days, VcR1 ~ 2mg on the 21st day and intermittent on the 11th day, Pred20mg, HMM with the same service, 6 to 8 courses for the whole course of treatment, the results: 40% Progress 40%, efficiency 80%, 23 patients with an average survival of 42 months (4.5 ~ 158 months), the median survival of 28 months. The authors believe that HOP can be used as one of the effective treatment of MM, the treatment should be closely followed blood.