1979年 Mueller 等报道:他们在探讨环孢菌素 A(Cyclosporin A,CSA)对类风湿性关节炎疗效的同时,也治疗了4例银屑病性关节炎,在治疗过程中发现 CSA 对银屑病皮肤损害具有意想不到的效果。4例严重而广泛的银屑病皮疹在用药剂量不等甚至是小剂量情况下,治疗5～7天内皮损几乎完全消退。这是 CSA 对皮肤病的第一篇报道。CSA 原来是作为抗真菌药进行研究的,但在1976年 Borel 发现它具有免疫抑制作用而指出 CSA 是一个新的抗淋巴细胞剂,之后引起医学界的重视,主要在西欧对它进行了体外和动物实验的广泛研究,并很快在 In 1979, Mueller et al reported that while they were discussing the effect of Cyclosporin A (CSA) on rheumatoid arthritis, they also treated 4 patients with psoriatic arthritis. During the treatment, they found that CSA had no effect on silver Skin lesions have an unexpected effect. 4 cases of severe and extensive psoriasis rash medication dose ranging from small doses, the treatment of 5 to 7 days, the skin lesions almost completely subsided. This is the first report of CSA on skin diseases. CSA was originally studied as an antifungal but in 1976 Borel found it immunosuppressed and pointed out that CSA is a new anti-lymphocyte agent that has drawn the attention of the medical community, mainly in Western Europe in vitro and in vitro Extensive research on animal experiments, and soon at