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目的:观察压力超负荷大鼠左心室肥厚的序列改变和保心康的干预作用。方法:普通级SD大鼠用缩窄腹主动脉的方法造成左心室压力超负荷,观察大鼠各时间点的心脏重量(CW)、左心室重量(LVW)、心脏质量指数(CMI)、左心室质量指数(LVMI)以及保心康的干预作用。结果:大鼠在造模后CW、LVW逐渐增加,约第30~40天之间,其增幅有所减少,CMI、LVMI亦随时间的延长而增加,约第30天达到最高值,到第40天时已开始降低;蒸馏水组大鼠心脏、左心室重量和心脏质量指数均明显高于假手术组(P<0.05或P<0.01),而保心康组大鼠心脏重量、左心室重量以及心脏质量指数与假手术组比较,无显著性差异(P>0.05)。结论:保心康可预防腹主动脉缩窄所引起的左心室肥厚。
Objective: To observe the sequence changes of left ventricular hypertrophy in pressure overload rats and the intervention effects of Baoxinkang. METHODS: Left ventricular pressure overload was induced by narrowing of the abdominal aorta in normal SD rats. Heart weight (CW), left ventricular mass (LVW), heart quality index (CMI), and left ventricular mass were measured at each time point. Ventricular quality index (LVMI) and Baoxinkang intervention. RESULTS: After CW and LVW were increased in rats, the amplitude of CW and LVW gradually decreased between the 30th and 40th days. The CMI and LVMI also increased with time, reaching the highest value on the 30th day. At the 40th day, it began to decrease; the heart, left ventricular mass and heart quality index of distilled water group were significantly higher than those of sham operation group (P<0.05 or P<0.01), while heart weight, left ventricular weight and There was no significant difference in the heart quality index compared with the sham group (P>0.05). Conclusion: Baoxinkang can prevent left ventricular hypertrophy caused by abdominal aortic coarctation.