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目的探讨血清蛋白电泳和免疫球蛋白的联合检测在临床上肝病患者中的应用价值,以供参考。方法以2015年10月-2016年9月本院收治的87例肝病患者(包括肝癌患者15例、慢性肝炎患者39例、肝硬化患者33例)以及87例健康者为研究对象,分别作为肝病组和对照组,对所有研究者血清样本进行电泳,检测血清中免疫球蛋白α1-球蛋白、γ-球蛋白、α2-球蛋白、β-球蛋白以及IgG、IgA、IgM的水平。结果慢性肝炎组α1-球蛋白、γ-球蛋白、IgG明显高于对照组,肝硬化组和肝癌组IgG、IgA、γ-球蛋白、α1-球蛋白水平均高于对照组,差异具有统计学意义(P<0.05)。结论血清中免疫球蛋白以及血清蛋白的含量与肝脏疾病密切相关,通过血清蛋白电泳和免疫球蛋白联合检测血清中免疫球蛋白α1-球蛋白、γ-球蛋白、α2-球蛋白、β-球蛋白以及IgG、IgA、IgM的水平对肝病的诊断具有重要意义,可在临床上推广应用。
Objective To explore the value of combined detection of serum protein electrophoresis and immunoglobulin in clinical patients with liver disease for reference. Methods 87 patients with liver disease (including 15 patients with liver cancer, 39 patients with chronic hepatitis and 33 patients with cirrhosis) and 87 healthy people admitted to our hospital from October 2015 to September 2016 were enrolled as liver disease Serum samples of all investigators were electrophoresed and serum levels of immunoglobulins α1-globulin, γ-globulin, α2-globulin, β-globulin, and IgG, IgA, and IgM were measured. Results The levels of α1-globulin, γ-globulin and IgG in chronic hepatitis group were significantly higher than those in control group. The levels of IgG, IgA, γ-globulin and α1-globulin in cirrhosis and hepatocellular carcinoma were higher than those in control group Significance (P <0.05). Conclusion Serum immunoglobulin and serum protein levels are closely related to liver diseases. Serum immunoglobulin α1-globulin, γ-globulin, α2-globulin and β-globin were detected by serum protein electrophoresis and immunoglobulin Protein and IgG, IgA, IgM levels of the diagnosis of liver disease is of great significance, which can be widely used in clinical practice.