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目的探讨恶性淋巴瘤患儿化疗期间综合护理干预的护理效果。方法选取2011年9月至2016年7月间哈尔滨医科大学附属肿瘤医院收治的160例非霍奇金淋巴瘤患儿,采用奇偶数字表法分为观察组与对照组,每组80例。两组患儿均给予常规化疗方案治疗,化疗期间,观察组患者在传统护理基础上采用综合护理,对照组患者采用传统护理,比较两组患者的疗效、不良反应、生活质量和生存时间。结果观察组患者有效率为76.3%,高于对照组患者的61.3%,差异有统计学意义(P<0.05)。治疗期间,观察组患者血液系统毒性及骨髓抑制等不良反应发生情况比对照组少,差异有统计学意义(P<0.05)。观察组患者治疗后,躯体功能、角色功能、情绪功能、认知功能与社会功能评分均明显高于对照组患者,差异均有统计学意义(均P<0.05)。随访至今,观察组患者无进展生存时间与总生存时间分别为(22.34±2.11)个月和(33.14±3.19)个月,对照组患者分别为(16.23±1.98)个月和(24.45±3.15)个月,两组比较,差异均有统计学意义(均P<0.05)。结论恶性淋巴瘤患儿化疗期间采用综合护理干预,能提高治疗效果,减少不良反应发生情况,改善生活质量,延长患者生存时间。
Objective To investigate the nursing effect of comprehensive nursing intervention in children with malignant lymphoma during chemotherapy. Methods From September 2011 to July 2016, 160 children with non-Hodgkin’s lymphoma who were admitted to Affiliated Tumor Hospital of Harbin Medical University were divided into observation group and control group with 80 cases in each group. The two groups of children were given routine chemotherapy regimen. During the chemotherapy, the patients in the observation group were treated with comprehensive nursing based on the traditional nursing. The patients in the control group were treated with traditional nursing care. The curative effect, adverse reactions, quality of life and survival time were compared between the two groups. Results The effective rate of the observation group was 76.3%, which was higher than that of the control group (61.3%), the difference was statistically significant (P <0.05). During the treatment, there was less incidence of adverse reactions such as hematological toxicity and bone marrow suppression in the observation group than in the control group, with significant difference (P <0.05). After treatment, the body function, role function, emotional function, cognitive function and social function score of the observation group were significantly higher than those of the control group, the differences were statistically significant (all P <0.05). During the follow-up, the progression-free survival time and total survival time in the observation group were (22.34 ± 2.11) months and (33.14 ± 3.19) months, respectively. The patients in the control group were (16.23 ± 1.98) months and (24.45 ± 3.15) Months, the differences between the two groups were statistically significant (all P <0.05). Conclusion Comprehensive nursing intervention during chemotherapy in children with malignant lymphoma can improve the therapeutic effect, reduce the incidence of adverse reactions, improve the quality of life, and prolong the survival time of patients.