论文部分内容阅读
目的研究中国南方汉族人群中白细胞介素-16(IL-16)基因-295 T>C多态性与肾透明细胞癌(CCRCC)易感性的相关性。方法采用以医院为基础的病例对照研究模式,通过面访填写调查表并采用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)方法检测年龄和性别匹配的中国南方汉族300例患者和300例正常人群的IL-16 gene-295 T>C基因型。并采用分层分析进一步探讨与罹患CCRCC相关的可能因素。结果与TT型携带者相比,CT型(OR=0.7 8,9 5%CI=0.5 5～1.09)或CC型(0.37,0.19～0.73)携带者发生CCRCC的危险性明显降低。分层分析显示年龄、体重指数及饮酒与CCRCC危险性之间无明显关联,携带CT或CC型从不吸烟的女性患者发生CCRCC的危险性明显降低(从不吸烟:0.61,0.41～0.91;女性:0.52,0.30～0.91)。结论 IL-16 gene-295 T>C多态性可能与我国南方地区汉族人群CCRCC易感性有关,CC型或CT型携带者发生CCRCC的危险性要明显低于TT型携带者。
Objective To investigate the association of polymorphism of interleukin-16 (IL-16) -295 T> C polymorphism with susceptibility to clear cell renal cell carcinoma (CCRCC) in Chinese Han population of southern China. Methods A hospital-based case-control study was conducted. The questionnaire was filled in by questionnaire and PCR-RFLP was used to detect 300 age-and-sex matched Han Chinese patients And IL-16 gene-295 T> C genotypes in 300 normal subjects. And stratified analysis to further explore the possible factors associated with CCRCC. Results Compared with TT carriers, the risk of developing CCRCC was significantly lower in patients with CT type (OR = 0.7 8, 95% CI 0.55 ~ 1.09) or carriers of CC type (0.37, 0.19-0.73). Stratified analysis showed no significant association between age, BMI and alcohol consumption and the risk of CCRCC. The risk of developing CCRCC in women with CT or CC never smoking was significantly lower (never smoking: 0.61, 0.41 to 0.91; female : 0.52, 0.30 ~ 0.91). CONCLUSION: The gene polymorphism of IL-16 gene-295 T> C may be related to the susceptibility to CCRCC in Han population of southern China. The risk of CCRCC in carriers with CC or CT is significantly lower than that of TT carriers.