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蛋白激酶CK2是一种真核细胞中普遍存在的多功能 ,丝氨酸 /苏氨酸蛋白激酶具有高度保守性。CK2全酶由两个催化亚基 (α和 /或α′亚基 )和两个调节亚基 β所构成。α/α′亚基具有催化活性 ,β亚基主要稳定及调节CK2的活性。CK2大量存在于大脑 ,而且集中分布于神经元及其突触 ,在突触形成、突触传递、信息传递和储存、生长、发育及神经元形态发生等方面发挥着重要作用 ;CK2对海马神经细胞具有营养刺激活性 ,其磷酸化作用与大脑的记忆功能有关 ;CK2可能在某些神经系统特异性病变 (如阿尔茨海默病 )病理过程中起到一定的作用
Protein kinase CK2 is a ubiquitous multifunctional, serine / threonine protein kinase that is highly conserved in eukaryotic cells. The CK2 holoenzyme consists of two catalytic subunits (α and / or α ’subunits) and two regulatory subunits β. α / α ’subunit has catalytic activity, β subunit is mainly stable and regulates CK2 activity. CK2 is found in a large number of brain and is distributed in neurons and synapses. CK2 plays an important role in synapse formation, synaptic transmission, information transmission and storage, growth, development and neuronal morphogenesis. Cells are nutritionally stimulatory and their phosphorylation is related to the memory function of the brain. CK2 may play a role in the pathological process of certain nervous system-specific diseases (such as Alzheimer’s disease)