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长期口服心得安的缺血性心脏病患者在急性停药后可出现心绞痛加剧、室上性或室性心律失常、心肌梗塞和猝死等,但其确切发生率和机制尚不明了.钙离子拮抗剂是治疗缺血性心脏病和室上性心律失常的重要药物,对其急性停药反应亦了解甚少.本文使用心得安和异搏停对心绞痛患者进行有安慰剂对照的随机双盲交叉试验,比较二药的抗心绞痛疗效和急性停药反应.方法:20名有稳定型心绞痛史3月以上的患者(19名男性,1名女性),每周心绞痛发作至少3次,平板运动试验时ST段有水平或下斜型压低至少1毫米并持续至J点后80毫秒.患者首先进行2周
Long-term oral propranolol ischemic heart disease in patients with acute withdrawal may occur after angina pectoris, supraventricular or ventricular arrhythmias, myocardial infarction and sudden death, but the exact incidence and mechanism is still unknown. Agent is an important drug for the treatment of ischemic heart disease and supraventricular arrhythmia, and its acute withdrawal response is also poorly understood.This article uses propranolol and verapamil for angina patients with placebo-controlled randomized double-blind crossover test , To compare the anti-anginal curative effect and acute withdrawal response of two drugs.Methods: Twenty patients with stable angina pectoris (19 males and one females) who had a history of stable angina were treated with weekly angina pectoris for at least 3 times during the treadmill exercise test The ST segment has a horizontal or downward sloping depression of at least 1 mm and lasts for 80 milliseconds after point J. Patients are first treated for 2 weeks