当Brunton首先用亚硝酸戊酯治疗心绞痛病人时,其目的是再产生放血样的低血压效应。一个多世纪以来,有关硝酸酯类缓解心绞痛的确切机理仍有争论。可能是由于不同的病人而异:对于那些典型的劳力性心绞痛患者,主要的病损很可能是冠状动脉狭窄;而那些不 When Brunton first used amyl nitrite to treat patients with angina, the goal was to reproduce the hypotensive effects of a bloodletting. For more than a century, the exact mechanism by which nitrates relieve angina remains controversial. It may be different for different patients: For those with typical exertional angina, the major lesion is likely to be coronary stenosis; those that do not