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本文测定32例原发性肝癌病人术前及术后第1、3、5、7天的动脉血酮体比率(AKBR)、凝血酶原时间(PT)、谷丙转氨酶(SGPT)和胆红素(SB)(包括直接胆红素(DSB)和总胆红素(TSB),并以7例慢性结石性胆囊炎病人作为对照。结果:①术前AK-BR≥0.7者,肝脏储备功能佳,能耐受各类肝切除术,术后并发症发生率少;AKBR≤0.4,肝脏储备功能极差,无法耐受任何方式的肝脏手术,死亡率高。②AKBR的值存在一个关键性临界范围0.25~0.4,在术后1~5天内AKBR值若持续停滞在这个区域,说明肝脏能量代谢极度低下,术后死亡率为100%。③AKBR与PT(活动度)、DSB和TSB存在一定的相关性,相关系数分别为0.568、-0.433和-0.478,P值均<0.001。以上结果表明临床现行的肝功能试验对评价肝功能的意义较小,难以确切地反映肝脏潜在的储备功能及预测手术风险。而AK-BR能准确地反映术前肝脏储备功能及其对手术的耐受性,能为评价手术风险性及指导围手术期的治疗提供可靠的依据。
The arterial blood ketone body ratio (AKBR), prothrombin time (PT), alanine aminotransferase (SGPT), and bilirubin were measured in 32 patients with primary liver cancer before surgery and on days 1, 3, 5, and 7 after surgery. SB (including direct bilirubin (DSB) and total bilirubin (TSB), and 7 patients with chronic cholecystitis as a control. Results: 1 preoperative AK-BR ≥ 0.7, liver Good reserve function, able to tolerate various types of hepatectomy, and low incidence of postoperative complications; AKBR ≤ 0.4, poor liver reserve function, inability to tolerate any form of liver surgery, high mortality rate.2 AKBR values exist A key critical range is 0.25-0.4, and if AKBR continues to stagnate in this area within 1 to 5 days after surgery, it indicates that the liver energy metabolism is extremely low and the postoperative mortality rate is 100%.3 AKBR and PT (Activity There is a certain correlation between DSB and TSB, with correlation coefficients of 0.568, -0.433, and -0.478, respectively. 0.001.The above results indicate that the current clinical liver function test has little significance in evaluating liver function, and it is difficult to accurately reflect the potential reserve function of the liver and predict the surgical risk, while AK-BR can accurately reflect the preoperative liver reserve function and Its tolerance to surgery can provide a reliable basis for evaluating surgical risk and guiding perioperative treatment.