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目的··:观察异博定对幼年大鼠吗啡成瘾后戒断症状的治疗作用。方法··:将50只SD幼鼠分为异博定治疗组(n=20)、实验对照组 (n=20)和阴性对照组 (n=10) ,建立吗啡成瘾幼鼠动物模型和吗啡戒断动物模型 ,用异博定对纳洛酮诱发的吗啡戒断幼鼠的戒断症状进行治疗 ,并分别对异博定治疗组和试验对照组吗啡成瘾及戒断症状进行观察和比较。结果··:给成瘾动物单次ip异博定 (10mg·kg-1)能明显缓解由纳洛酮诱发的吗啡戒断症状 ,并对吗啡戒断引起的体重下降有减轻作用。而连续3d治疗能明显加速纳洛酮诱发的戒断症状的缓解 ,且与试验对照组比较有显著性差异 (P<0.01)。结论··:异博定对纳洛酮诱发的幼年大鼠吗啡戒断症状有一定治疗作用。
Objective: · To observe the effect of isobording on the withdrawal symptoms of morphine addiction in juvenile rats. Methods · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · - Morphine withdrawal animal model, using isoprofen naloxone-induced morphine withdrawal symptoms in young rats were treated and morphine addiction and withdrawal symptoms were observed and Compare Results ·····································································································································. Continuous 3d treatment can obviously accelerate the withdrawal of withdrawal symptoms induced by naloxone, and there is a significant difference compared with the experimental control group (P <0.01). Conclusion · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · Information Name: Diflubin on morphine withdrawal symptoms induced by naloxone in juvenile rats.