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目的检测2型糖尿病合并牙周病患者血中炎性标志物C反应蛋白(CRP)和肿瘤坏死因子(TNF)-α水平的变化,探讨二者与糖尿病牙周病的关系。方法对584例2型糖尿病患者进行牙周病的筛查,检测血CRP、TNF-α与健康体检配对人群进行相关指标比较。结果2型糖尿病牙周病的患病率高达63.7%,对照组为21.6%。糖尿病合并牙周病患者CRP为(8.4±0.9)mg/L,糖尿病无牙周病患者为(5.9±0.8)mg/L,两者差异有统计学意义(P<0.01)。TNF-α在糖尿病合并牙周病组为(234±28)ng/L,明显较糖尿病无牙周病组的[(178±28)ng/L]增高(P<0.01)。结论糖尿病与牙周病两者互相影响,相互促进,导致牙周病加重及糖尿病大血管并发症进展。
Objective To investigate the changes of blood levels of C reactive protein (CRP) and tumor necrosis factor (TNF) -α in patients with type 2 diabetes mellitus complicated with periodontal disease and to explore their relationship with periodontal disease of diabetes mellitus. Methods 584 patients with type 2 diabetes mellitus were tested for periodontal disease. The blood levels of CRP and TNF-α were compared with those of healthy counterparts. Results The prevalence of periodontal disease in type 2 diabetes patients was as high as 63.7% and in control group 21.6%. The CRP of diabetic patients with periodontal disease was (8.4 ± 0.9) mg / L and that of diabetic patients without periodontal disease was (5.9 ± 0.8) mg / L, the difference was statistically significant (P <0.01). The level of TNF-α was (234 ± 28) ng / L in diabetic patients with periodontal disease (P <0.01), which was significantly higher than that of diabetic periodontal disease patients (178 ± 28 ng / L). Conclusion Both diabetes and periodontal disease affect each other and promote each other, leading to the increase of periodontal disease and the progression of diabetic macrovascular complications.