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本文报告了多发性骨髓瘤患者的抗个体型抗体的研制方法。用该抗体检测了所对应患者的外周血淋巴细胞。结果提示：（1）抗个体型抗体仅对患者的M蛋白和血清起反应，对其它M蛋白血清和正常人血清不发生反应。（2）外周血检测出了对抗个体型抗体反应的阳性淋巴细胞。说明多发性骨髓瘤患者的异常克隆发生在B细胞阶段。
This article reports the development of anti-idiotypic antibodies in patients with multiple myeloma. The antibody was used to detect peripheral blood lymphocytes of the corresponding patient. The results suggest that: (1) anti-idiotypic antibodies only react to the patient’s M protein and serum, and do not respond to other M protein serum and normal human serum. (2) Peripheral blood was detected positive lymphocytes against individual antibody responses. Description of abnormal myeloma patients with abnormal cloning in the B cell stage.