血小板源性生长因子(PDGF)可以刺激多种细胞分裂和增殖,许多血管性疾病的发生发展都有其参与。找出PDGF-B与血管增生、肥厚的关系,既能保留它正常生理功能,又能防止和减轻血管性疾病。本文就PDGF-B所致的血管平滑肌细胞异常增殖的信号转导机制以及调节因素研究进展作一综述,旨在为临床防治动脉硬化、血管损伤再狭窄、高血压等心血管系统疾病提供研究方向。 Platelet-derived growth factor (PDGF) can stimulate a variety of cell division and proliferation, many vascular diseases have their participation in the development. Find the relationship between PDGF-B and vascular proliferation, hypertrophy, both to retain its normal physiological function, but also to prevent and reduce vascular disease. This review summarizes the signal transduction mechanism of PDGF-B-induced abnormal proliferation of vascular smooth muscle cells and its regulatory factors, and aims to provide a research direction for the prevention and treatment of cardiovascular diseases such as arteriosclerosis, vascular injury and restenosis, and hypertension .