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尽管有人对系统性血管炎进行了免疫学及病理学研究,但其发病机理仍不很清楚。细胞因子之一α—肿瘤坏死因子(TNF—α,恶液质素)具有各种生物学活性,常伴有急、慢性炎症,可作为休克的外源性介质。作者在对系统性血管炎(结节性动脉周炎及Wegener肉芽肿)患者外周血单核细胞的细胞因子系统(cytokine systems)及细胞激活的研究中,发现TNF—α基因转录增加,但肌纤维蛋白转录正常。作者还通过Southern印迹分析检测了TNF—α基因的DNA放大及交叉易位,但这两种现象均未观察到。
Although systemic immunological and pathological studies have been conducted on systemic vasculitis, its pathogenesis is still unclear. Alpha-tumor necrosis factor (TNF-alpha, celiac fluid), one of the cytokines, has a variety of biological activity, often accompanied by acute and chronic inflammation, can be used as exogenous media of shock. In the study of cytokine systems and cell activation of peripheral blood mononuclear cells in patients with systemic vasculitis (nodular arteritis and Wegener’s granulomatosis), the authors found that TNF-α gene transcription is increased, but muscle fibers Protein transcription is normal. The authors also examined DNA amplification and cross-metathesis of the TNF-a gene by Southern blot analysis, but neither of these phenomena was observed.